PRC1 drives Polycomb-mediated gene repression by controlling transcription initiation and burst frequency
The Polycomb repressive system plays a fundamental role in controlling gene expression during mammalian development. To achieve this, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) bind target genes and use histone modification-dependent feedback mechanisms to form Polycomb chromatin domains...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cold Spring Harbor Laboratory
2020
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