Use of SSCP analysis to identify germline mutations in HNPCC families fulfilling the Amsterdam criteria.
Hereditary non-polyposis colorectal cancer (HNPCC) is a clinical syndrome characterised by an inherited predisposition to early onset colorectal and uterine cancers and an increased incidence of other cancers. It is caused by germline defects in the human mismatch repair genes. Defects in two of the...
Main Authors: | Beck, N, Tomlinson, I, Homfray, T, Frayling, I, Hodgson, S, Harocopos, C, Bodmer, W |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
1997
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פריטים דומים
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Germline HNPCC gene variants have little influence on the risk for sporadic colorectal cancer.
מאת: Tomlinson, I, et al.
יצא לאור: (1997) -
Genetic testing is important in families with a history suggestive of hereditary non-polyposis colorectal cancer even if the Amsterdam criteria are not fulfilled.
מאת: Beck, N, et al.
יצא לאור: (1997) -
Molecular and clinico-pathological features of two families with the HNPCC syndrome and unusual phenotypes
מאת: Tomlinson, I, et al.
יצא לאור: (1997) -
Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
מאת: Beck, N, et al.
יצא לאור: (1997) -
Analysis of somatic molecular changes, clinicopathological features, family history, and germline mutations in colorectal cancer families: evidence for efficient diagnosis of HNPCC and for the existence of distinct groups of non-HNPCC families.
מאת: Johnson, V, et al.
יצא לאור: (2005)