Dimerization of complement factor H-related proteins modulates complement activation in vivo.

The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus. Elucidating the mechanism underlying these associations ha...

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Bibliographic Details
Main Authors: Goicoechea de Jorge, E, Caesar, J, Malik, T, Patel, M, Colledge, M, Johnson, S, Hakobyan, S, Morgan, B, Harris, C, Pickering, M, Lea, S
Format: Journal article
Language:English
Published: 2013