iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition
The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incomple...
Main Authors: | , , , , , , , , , , , |
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Format: | Journal article |
Published: |
National Academy of Sciences
2019
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