iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition

The most frequently mutated protein in human cancer is p53, a transcription factor (TF) that regulates myriad genes instrumental in diverse cellular outcomes including growth arrest and cell death. Cell context-dependent p53 modulation is critical for this life-or-death balance, yet remains incomple...

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Bibliographic Details
Main Authors:	Chen, S, Wu, J, Zhong, S, Li, Y, Zhang, P, Ma, J, Ren, J, Tan, Y, Siebold, C, Bond, G, Bond, Y, Lu, X
Format:	Journal article
Published:	National Academy of Sciences 2019

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