A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.

A DNA prime-modified vaccinia virus ankara boost vaccine encoding thrombospondin-related adhesion protein but not circumsporozoite protein partially protects healthy malaria-naive adults against Plasmodium falciparum sporozoite challenge.

The safety, immunogenicity, and efficacy of DNA and modified vaccinia virus Ankara (MVA) prime-boost regimes were assessed by using either thrombospondin-related adhesion protein (TRAP) with a multiple-epitope string ME (ME-TRAP) or the circumsporozoite protein (CS) of Plasmodium falciparum. Sixteen...

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Bibliographic Details
Main Authors: Dunachie, S, Walther, M, Epstein, J, Keating, S, Berthoud, T, Andrews, L, Andersen, R, Bejon, P, Goonetilleke, N, Poulton, I, Webster, D, Butcher, G, Watkins, K, Sinden, R, Levine, G, Richie, T, Schneider, J, Kaslow, D, Gilbert, S, Carucci, D, Hill, A
Format: Journal article
Language:English
Published: 2006

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