Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

Identification of the PIP2-binding site on Kir6.2 by molecular modelling and functional analysis.

ATP-sensitive potassium (K(ATP)) channels couple cell metabolism to electrical activity by regulating K(+) fluxes across the plasma membrane. Channel closure is facilitated by ATP, which binds to the pore-forming subunit (Kir6.2). Conversely, channel opening is potentiated by phosphoinositol bisphos...

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Autors principals:	Haider, S, Tarasov, A, Craig, T, Sansom, M, Ashcroft, F
Format:	Journal article
Idioma:	English
Publicat:	2007

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