Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.

Blocking variant surface glycoprotein synthesis in Trypanosoma brucei triggers a general arrest in translation initiation.

BACKGROUND: The African trypanosome Trypanosoma brucei is covered with a dense layer of Variant Surface Glycoprotein (VSG), which protects it from lysis by host complement via the alternative pathway in the mammalian bloodstream. Blocking VSG synthesis by the induction of VSG RNAi triggers an unusu...

Полное описание

Библиографические подробности
Главные авторы:	Smith, T, Vasileva, N, Gluenz, E, Terry, S, Portman, N, Kramer, S, Carrington, M, Michaeli, S, Gull, K, Rudenko, G
Формат:	Journal article
Язык:	English
Опубликовано:	Public Library of Science 2009

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