Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation

Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation

Histopathological studies have revealed key processes of atherosclerotic plaque thrombosis. However, the diversity and complexity of lesion types highlight the need for improved sub-phenotyping. Here we analyze the gene expression profiles of 654 advanced human carotid plaques. The unsupervised, tra...

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Egile Nagusiak: Mokry, M, Boltjes, A, Slenders, L, Bel-Bordes, G, Cui, K, Brouwer, E, Mekke, JM, Depuydt, MAC, Timmerman, N, Waissi, F, Verwer, MC, Turner, AW, Khan, MD, Hodonsky, CJ, Benavente, ED, Hartman, RJG, van den Dungen, NAM, Lansu, N, Nagyova, E, Prange, KHM, Kovacic, JC, Björkegren, JLM, Pavlos, E, Andreakos, E, Schunkert, H, Owens, GK, Monaco, C, Finn, AV, Virmani, R, Leeper, NJ, de Winther, MPJ, Kuiper, J, de Borst, GJ, Stroes, ESG, Civelek, M, de Kleijn, DPV, den Ruijter, HM, Asselbergs, FW, van der Laan, SW, Miller, CL, Pasterkamp, G
Formatua: Journal article
Hizkuntza:English
Argitaratua: Springer Nature 2022

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