Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.

Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.

HIV-specific CTL play a central role in immune control of HIV. The basis for understanding the success or failure of this immune response requires identification of the specific epitopes targeted by CTL. However, in populations most severely affected by the global epidemic, this fundamental knowledg...

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Bibliografische gegevens
Hoofdauteurs:	Honeyborne, I, Rathod, A, Buchli, R, Ramduth, D, Moodley, E, Rathnavalu, P, Chetty, S, Day, C, Brander, C, Hildebrand, W, Walker, B, Kiepiela, P, Goulder, P
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2006

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Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. (vol 177, pg 4699, 2006)
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Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
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Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
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Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.
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Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restrieted gag epitope in chronic human immunodeficiency virus type 1 infection (vol 81, pg 8346, 2007)
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P09-19 LB. CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity
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Definition of peptide binding motifs amongst the HLA-A*30 allelic group.
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Rare HLA drive additional HIV evolution compared to more frequent alleles.
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CTL epitope escape and reversion in acute HCV infection.
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Identification of class I HLA T cell control epitopes for West Nile virus.
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P16-04. Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infection
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Revisiting the Influence of HLA-type, Frequency, HLA-supertype and Homozygosity on the Immune Control of HIV
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