Characterisation of the changing genomic landscape of metastatic melanoma using cell free DNA

Cancer is characterised by complex somatically acquired genetic aberrations that manifest as intra-tumour and inter-tumour genetic heterogeneity and can lead to treatment resistance. In this case study, we characterise the genome-wide somatic mutation dynamics in a metastatic melanoma patient during...

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Bibliographic Details
Main Authors: Cutts, A, Venn, O, Dilthey, A, Gupta, A, Vavoulis, D, Dreau, H, Middleton, M, McVean, G, Taylor, J, Schuh, A
Format: Journal article
Language:English
Published: Nature Publishing Group 2017