Molecular modifiers of T cell antigen receptor triggering threshold: the mechanism of CD28 costimulatory receptor.

CD28 was thought to represent a prototypic membrane receptor responsible for delivering the classically defined 'second signal' needed to avoid T cell paralysis when recognizing antigen presented by appropriate antigen presenting cells (APCs). Almost two decades after its molecular identif...

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Bibliographic Details
Main Authors: Acuto, O, Mise-Omata, S, Mangino, G, Michel, F
Format: Journal article
Language:English
Published: 2003