A theoretical investigation of the effect of proliferation & adhesion on monoclonal conversion in the colonic crypt

The surface epithelium lining the intestinal tract renews itself rapidly by a coordinated programme of cell proliferation, migration and differentiation events that is initiated in the crypts of Lieberkühn. It is generally believed that colorectal cancer arises due to mutations that disrupt the norm...

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Bibliographic Details
Main Authors: Mirams, G, Fletcher, A, Maini, P, Byrne, H
Format: Journal article
Published: Elsevier 2012