Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer.

Dystrophic phenotype of canine X-linked muscular dystrophy is mitigated by adenovirus-mediated utrophin gene transfer.

Utrophin is highly homologous and structurally similar to dystrophin, and in gene delivery experiments in mdx mice was able to functionally replace dystrophin. We performed mini-utrophin gene transfer in Golden Retriever dogs with canine muscular dystrophy (CXMD). Unlike the mouse model, the clinico...

书目详细资料
Main Authors:	Cerletti, M, Negri, T, Cozzi, F, Colpo, R, Andreetta, F, Croci, D, Davies, K, Cornelio, F, Pozza, O, Karpati, G, Gilbert, R, Mora, M
格式:	Journal article
语言:	English
出版:	2003

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