Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes
Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strate...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1797064158437441536 |
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| author | Bicknell, K Coxon, C Brooks, G |
| author_facet | Bicknell, K Coxon, C Brooks, G |
| author_sort | Bicknell, K |
| collection | OXFORD |
| description | Repair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury. |
| first_indexed | 2024-03-06T21:10:15Z |
| format | Journal article |
| id | oxford-uuid:3de4bcfb-2417-4e6d-b8c3-e29b47c0c4eb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:10:15Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:3de4bcfb-2417-4e6d-b8c3-e29b47c0c4eb2022-03-26T14:22:11ZForced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3de4bcfb-2417-4e6d-b8c3-e29b47c0c4ebEnglishSymplectic Elements at Oxford2004Bicknell, KCoxon, CBrooks, GRepair of the mature mammalian myocardium following injury is impaired by the inability of the majority of cardiomyocytes to undergo cell division. We show that overexpression of the cyclin B1-CDC2 (cell division cycle 2 kinase) complex re-initiates cell division in adult cardiomyocytes. Thus strategies targeting the cyclin B1-CDC2 complex might re-initiate cell division in mature cardiomyocytes in vivo and facilitate myocardial regeneration following injury. |
| spellingShingle | Bicknell, K Coxon, C Brooks, G Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes |
| title | Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes |
| title_full | Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes |
| title_fullStr | Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes |
| title_full_unstemmed | Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes |
| title_short | Forced expression of the cyclin B1-CDC2 complex induces proliferation in adult rat cardiomyocytes |
| title_sort | forced expression of the cyclin b1 cdc2 complex induces proliferation in adult rat cardiomyocytes |
| work_keys_str_mv | AT bicknellk forcedexpressionofthecyclinb1cdc2complexinducesproliferationinadultratcardiomyocytes AT coxonc forcedexpressionofthecyclinb1cdc2complexinducesproliferationinadultratcardiomyocytes AT brooksg forcedexpressionofthecyclinb1cdc2complexinducesproliferationinadultratcardiomyocytes |