The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas.

The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas.

BACKGROUND: p53 mutations are frequently observed in colorectal carcinomas but they have also been found in colorectal adenomas, although considerably less frequently. AIMS: To explore p53 mutations in benign tumours, we have screened 70 colorectal adenomas for allelic loss at, and point mutations i...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Hao, X, Frayling, I, Sgouros, J, Du, M, Willcocks, T, Talbot, I, Tomlinson, I
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2002

Eitemau Tebyg

Loss of heterozygosity at APC and beta-catenin expression in sporadic colorectal carcinogenesis
gan: Hao, X, et al.
Cyhoeddwyd: (1998)

Frequency of germline hereditary non-polyposis colorectal cancer gene mutations in patients with multiple or early onset colorectal adenomas.
gan: Beck, N, et al.
Cyhoeddwyd: (1997)

Reduced expression of molecules of the cadherin/catenin complex in the transition from colorectal adenoma to carcinoma.
gan: Hao, X, et al.
Cyhoeddwyd: (1997)

Beta-catenin expression and allelic loss at APC in sporadic colorectal carcinogenesis.
gan: Hao, X, et al.
Cyhoeddwyd: (2002)

APC mutations are sufficient for the growth of early colorectal adenomas.
gan: Lamlum, H, et al.
Cyhoeddwyd: (2000)

Inherited susceptibility to colorectal adenomas and carcinomas: evidence for a new predisposition gene on 15q14-q22.
gan: Tomlinson, I, et al.
Cyhoeddwyd: (1999)

The interplay between p53 and p21 tumor suppressor proteins in the transformation of colorectal adenoma to carcinoma.
gan: Abdulamir, Ahmed Sahib, et al.
Cyhoeddwyd: (2008)

Expression and clinicopathologic significance of TUFM and p53 for the normal–adenoma–carcinoma sequence in colorectal epithelia
gan: Hong-Qing Xi, et al.
Cyhoeddwyd: (2017-04-01)

KRAS and TP53 mutations in colorectal carcinoma
gan: Al-Kuraya Khawla
Cyhoeddwyd: (2009-01-01)

Immunohistochemical evaluation of p53 and Ki-67 proteins in colorectal adenomas
gan: Walysson Alves Tocantins de Sousa, et al.
Cyhoeddwyd: (2012-03-01)

Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.
gan: Thirlwell, C, et al.
Cyhoeddwyd: (2007)

Intratumor Heterogeneity of K-Ras and p53 Mutations among Human Colorectal Adenomas Containing Early Cancer
gan: Walter Giaretti, et al.
Cyhoeddwyd: (2000-01-01)

Intratumor Heterogeneity of k-ras and p53 Mutations Among Human Colorectal Adenomas Containing Early Cancer
gan: Walter Giaretti
Cyhoeddwyd: (2001-01-01)

Clinico-pathological features and p53 expression in left-sided sporadic colorectal cancers with and without microsatellite instability.
gan: Ilyas, M, et al.
Cyhoeddwyd: (1996)

p16 protein is upregulated in a stepwise fashion in colorectal adenoma and colorectal carcinoma
gan: Mahmoud Al-Ahwal, et al.
Cyhoeddwyd: (2016-01-01)

p53 Mutations and DNA Ploidy in Colorectal Adenocarcinomas
gan: Paola Campomenosi, et al.
Cyhoeddwyd: (1998-01-01)

Study of the expression of oncoprotein p53, EGFR in colorectal carcinomas with different proliferative activity
gan: I.S. Shponka, et al.
Cyhoeddwyd: (2023-04-01)

Immunohistochemical Expression of ki-67 and p53 in Colorectal Adenomas: A Clinicopathological Study
gan: Hussam Hasson Ali, et al.
Cyhoeddwyd: (2011-07-01)

Multiple colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH.
gan: Sieber, O, et al.
Cyhoeddwyd: (2003)

Comprehensive mutation analysis in colorectal flat adenomas.
gan: Quirinus J M Voorham, et al.
Cyhoeddwyd: (2012-01-01)

APC mutation spectrum in ileoanal pouch polyps resembles that of colorectal polyps.
gan: Will, O, et al.
Cyhoeddwyd: (2008)

Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
gan: Sieber, O, et al.
Cyhoeddwyd: (2002)

The multiple colorectal adenoma phenotype and MYH, a base excision repair gene.
gan: Lipton, L, et al.
Cyhoeddwyd: (2004)

Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome.
gan: Johnson, V, et al.
Cyhoeddwyd: (2005)

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.
gan: Lipton, L, et al.
Cyhoeddwyd: (2003)

Intestinal Microbiota in Colorectal Adenoma-Carcinoma Sequence
gan: Hanju Hua, et al.
Cyhoeddwyd: (2022-07-01)

Association of p53, VEGF and Microvascular Density in Colorectal Carcinoma
gan: RITUPARNA GHOSH, et al.
Cyhoeddwyd: (2020-08-01)

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
gan: Palles, C, et al.
Cyhoeddwyd: (2013)

Mutations in the P53 Tumor Suppressor Gene in Colorectal Cancer in Taiwan
gan: Fu-Hsin Chang, et al.
Cyhoeddwyd: (2003-04-01)

Regression of colorectal adenoma
gan: Subin Song, et al.
Cyhoeddwyd: (2023-07-01)

Synchronous colorectal adenomas
gan: Radovanović-Dinić Biljana, et al.
Cyhoeddwyd: (2010-01-01)

Allele loss in colorectal cancer at the Cowden disease/juvenile polyposis locus on 10q.
gan: Frayling, I, et al.
Cyhoeddwyd: (1997)

Reciprocity between membranous and nuclear expression of beta-catenin in colorectal tumours.
gan: Hao, X, et al.
Cyhoeddwyd: (1997)

Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.
gan: Suraweera, N, et al.
Cyhoeddwyd: (2006)

The expression and mutation of β-catenin in colorectal traditional serrated adenomas
gan: Xiaojun Dai, et al.
Cyhoeddwyd: (2012-01-01)

Author Correction: Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
gan: Jiri Jungwirth, et al.
Cyhoeddwyd: (2022-10-01)

Association between cigarette smoking, <it>APC </it>mutations and the risk of developing sporadic colorectal adenomas and carcinomas
gan: Hagen Per, et al.
Cyhoeddwyd: (2006-03-01)

Author Correction: Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
gan: Jiri Jungwirth, et al.
Cyhoeddwyd: (2022-04-01)

Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
gan: Liu, Y, et al.
Cyhoeddwyd: (2006)

Top down or bottom up morphogenesis of colorectal adenomas: Competing management structures in the origins of colorectal neoplasia
gan: Preston, S, et al.
Cyhoeddwyd: (2003)