Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

Eitemau Tebyg

• The cyclooxygenase-2 inhibitor GW406381X [2-(4-ethoxyphenyl)-3-[4-(methylsulfonyl)phenyl]-pyrazolo[1,5-b]pyridazine] is effective in animal models of neuropathic pain and central sensitization.
  gan: Bingham, S, et al.
  Cyhoeddwyd: (2005)
• Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
  gan: Beswick, P, et al.
  Cyhoeddwyd: (2009)
• Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
  gan: Swarbrick, M, et al.
  Cyhoeddwyd: (2009)
• 3,4,7-Trimethyl-2-(4-methylphenyl)-2H-pyrazolo[3,4-d]pyridazin-5-ium thiocyanate
  gan: Abdel-Aziz, H.A., et al.
  Cyhoeddwyd: (2010)
• Cyclooxygenase-2 (Cox-2) in injured human nerve and a rat model of nerve injury.
  gan: Durrenberger, P, et al.
  Cyhoeddwyd: (2004)