Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry. Cartilage explants were cultured in medium containing [35S]methionine/cysteine to radiolabel newly synthesized...

書誌詳細
主要な著者:	Hermansson, M, Sawaji, Y, Bolton, M, Alexander, S, Wallace, A, Begum, S, Wait, R, Saklatvala, J
フォーマット:	Journal article
言語:	English
出版事項:	2004

類似資料

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
著者:: Alexander, S, 等
出版事項: (2007)

Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
著者:: Vincent, T, 等
出版事項: (2002)

Induction of interleukin-1 in articular cartilage by explantation and cutting.
著者:: Gruber, J, 等
出版事項: (2004)

Two-dimensional electrophoresis of proteins secreted from articular cartilage.
著者:: Hermansson, M, 等
出版事項: (2007)

Basic fibroblast growth factor (FGF) mediator of the immediate injury response in articular cartilage
著者:: Vincent, T, 等
出版事項: (2001)

BASIC FIBROBLAST GROWTH FACTOR (bFGF) MEDIATES THE IMMEDIATE INJURY RESPONSE IN ARTICULAR CARTILAGE
著者:: Vincent, T, 等
出版事項: (2002)

Activin is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
著者:: Watt, F, 等
出版事項: (2008)

Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage
著者:: Didangelos, A, 等
出版事項: (2009)

Activin A is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
著者:: Watt, F, 等
出版事項: (2009)

Pericellular matrix of articular cartilage. A novel mechanotransduction mechanism in articular chondrocytes?
著者:: Vincent, T, 等
出版事項: (2006)

Activins and Inhibins in Cardiovascular Pathophysiology
著者:: Wenyi Tang, 等
出版事項: (2024-11-01)

Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage
著者:: Sawaji, Y, 等
出版事項: (2009)

Dexamethasone inhibits aggrecanolysis in human articular cartilage but promotes it in porcine tissue
著者:: Sawaji, Y, 等
出版事項: (2009)

Changes in the reproductive function and developmental phenotypes in mice following intramuscular injection of an activin betaA-expressing plasmid
著者:: Mayo Kelly E, 等
出版事項: (2008-12-01)

INTERLEUKIN 1 INDUCES AGGRECAN DEGRADATION BY HUMAN ARTICULAR CHONDROCYTES THROUGH A TAK1/MKK4/JNK2 PATHWAY WITHOUT INVOLVEMENT OF NFKB
著者:: Ismail, H, 等
出版事項: (2013)

Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis.
著者:: Peng Li, 等
出版事項: (2024-01-01)

Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.
著者:: Sawaji, Y, 等
出版事項: (2008)

FUNCTIONS OF THE mTOR SIGNALING PATHWAY IN NORMAL ARTICULAR CARTILAGE CHONDROCYTES AND IN OSTEOARTHRITIS
著者:: E. V. Chetina, 等
出版事項: (2016-12-01)

Wounding articular cartilage rapidly activates multiple signalling events in chondrocytes involving protein phosphorylation and polyubiquitination
著者:: Ismail, H, 等
出版事項: (2014)

Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A
著者:: Yusuke Arino, 等
出版事項: (2025-02-01)

The effects of age and cell isolation on collagen II synthesis by articular chondrocytes: evidence for transcriptional and posttranscriptional regulation
著者:: Asopa, V, 等
出版事項: (2020)

Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes
著者:: Watt, F, 等
出版事項: (2006)

Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder
著者:: Weipu Mao, 等
出版事項: (2025-03-01)

The minor collagens in articular cartilage
著者:: Yunyun Luo, 等
出版事項: (2017-02-01)

Articular cartilage injury rapidly activates TAK1 in chondrocytes by inducing its phosphorylation and K63-polyubiquitination
著者:: Ismail, H, 等
出版事項: (2017)

FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.
著者:: Vincent, T, 等
出版事項: (2007)

Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.
著者:: Saklatvala, J
出版事項: (2007)

Genetic analysis of activin/inhibin β subunits in zebrafish development and reproduction.
著者:: Cheng Zhao, 等
出版事項: (2022-12-01)

Articular Cartilage Regeneration in Osteoarthritis
著者:: Livia Roseti, 等
出版事項: (2019-10-01)

Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome
著者:: Ping Shen, 等
出版事項: (2022-11-01)

The fate of implanted autologous chondrocytes in regenerated articular cartilage.
著者:: Min, B, 等
出版事項: (2007)

Articular cartilage collagen: an irreplaceable framework?
著者:: D R Eyre, 等
出版事項: (2006-11-01)

Articular cartilage collagen: an irreplaceable framework?
著者:: DR Eyre, 等
出版事項: (2006-11-01)

Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.
著者:: Vincent, T, 等
出版事項: (2004)

Immunolocalization of activin and inhibin at different stages of follicular development in the lizard Sceloporus torquatus
著者:: N.B. Cruz-Cano, 等
出版事項: (2023-09-01)

Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas
著者:: J. J. Staudacher, 等
出版事項: (2022-09-01)

The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation
著者:: Reichardt Holger M, 等
出版事項: (2008-05-01)

Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration
著者:: Hemanth Akkiraju, 等
出版事項: (2015-12-01)

NG2/HMPG modulation of human articular chondrocyte adhesion to type VI collagen is lost in osteoarthritis.
著者:: Midwood, K, 等
出版事項: (2001)

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.
著者:: Gardiner, MD, 等
出版事項: (2014)