Semisynthetic nanoreactor for reversible single-molecule covalent chemistry.

Protein engineering has been used to remodel pores for applications in biotechnology. For example, the heptameric α-hemolysin pore (αHL) has been engineered to form a nanoreactor to study covalent chemistry at the single-molecule level. Previous work has been confined largely to the chemistry of cys...

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Bibliographic Details
Main Authors: Lee, J, Boersma, A, Boudreau, M, Cheley, S, Daltrop, O, Li, J, Tamagaki, H, Bayley, J
Format: Journal article
Language:English
Published: American Chemical Society 2016