Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.

Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.

We describe a family in which alpha-thalassemia occurs in association with a deletion of 62 kilobases from a region upstream of the alpha globin genes. DNA sequence analysis has shown that the transcription units of both alpha genes downstream of this deletion are normal. Nevertheless, they fail to...

Полное описание

Библиографические подробности
Главные авторы:	Hatton, C, Wilkie, A, Drysdale, H, Wood, W, Vickers, M, Sharpe, J, Ayyub, H, Pretorius, I, Buckle, V, Higgs, D
Формат:	Journal article
Язык:	English
Опубликовано:	1990

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