Cutting edge: HLA-B27 can form a novel beta 2-microglobulin-free heavy chain homodimer structure.
HLA-B27 has a striking association with inflammatory arthritis. We show that free HLA-B27 heavy chains can form a disulfide-bonded homodimer, dependent on residue Cys67 in their extracellular alpha 1 domain. Despite the absence of beta 2-microglobulin, HLA-B27 heavy chain homodimers (termed HC-B27)...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1999
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