SH2 domains: modulators of nonreceptor tyrosine kinase activity.
The Src homology 2 (SH2) domain is a sequence-specific phosphotyrosine-binding module present in many signaling molecules. In cytoplasmic tyrosine kinases, the SH2 domain is located N-terminally to the catalytic kinase domain (SH1) where it mediates cellular localization, substrate recruitment, and...
| Auteurs principaux: | , , |
|---|---|
| Format: | Journal article |
| Langue: | English |
| Publié: |
2009
|