Dissociation of gp120 from HIV-1 virions induced by soluble CD4.
The CD4 antigen is the high affinity cellular receptor for the human immunodeficiency virus type-1 (HIV-1). Binding of recombinant soluble CD4 (sCD4) or the purified V1 domain of sCD4 to the surface glycoprotein gp120 on virions resulted in rapid dissociation of gp120 from its complex with the trans...
| Asıl Yazarlar: | , , , |
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| Materyal Türü: | Journal article |
| Dil: | English |
| Baskı/Yayın Bilgisi: |
1990
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| _version_ | 1826268735028068352 |
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| author | Moore, J McKeating, J Weiss, R Sattentau, Q |
| author_facet | Moore, J McKeating, J Weiss, R Sattentau, Q |
| author_sort | Moore, J |
| collection | OXFORD |
| description | The CD4 antigen is the high affinity cellular receptor for the human immunodeficiency virus type-1 (HIV-1). Binding of recombinant soluble CD4 (sCD4) or the purified V1 domain of sCD4 to the surface glycoprotein gp120 on virions resulted in rapid dissociation of gp120 from its complex with the transmembrane glycoprotein gp41. This may represent the initial stage in virus-cell and cell-cell fusion. Shedding of gp120 from virions induced by sCD4 may also contribute to the mechanism by which these soluble receptor molecules neutralize HIV-1. |
| first_indexed | 2024-03-06T21:14:09Z |
| format | Journal article |
| id | oxford-uuid:3f32fdff-7ec8-4fa9-b941-a3101ea8c8fc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:14:09Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:3f32fdff-7ec8-4fa9-b941-a3101ea8c8fc2022-03-26T14:30:26ZDissociation of gp120 from HIV-1 virions induced by soluble CD4.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f32fdff-7ec8-4fa9-b941-a3101ea8c8fcEnglishSymplectic Elements at Oxford1990Moore, JMcKeating, JWeiss, RSattentau, QThe CD4 antigen is the high affinity cellular receptor for the human immunodeficiency virus type-1 (HIV-1). Binding of recombinant soluble CD4 (sCD4) or the purified V1 domain of sCD4 to the surface glycoprotein gp120 on virions resulted in rapid dissociation of gp120 from its complex with the transmembrane glycoprotein gp41. This may represent the initial stage in virus-cell and cell-cell fusion. Shedding of gp120 from virions induced by sCD4 may also contribute to the mechanism by which these soluble receptor molecules neutralize HIV-1. |
| spellingShingle | Moore, J McKeating, J Weiss, R Sattentau, Q Dissociation of gp120 from HIV-1 virions induced by soluble CD4. |
| title | Dissociation of gp120 from HIV-1 virions induced by soluble CD4. |
| title_full | Dissociation of gp120 from HIV-1 virions induced by soluble CD4. |
| title_fullStr | Dissociation of gp120 from HIV-1 virions induced by soluble CD4. |
| title_full_unstemmed | Dissociation of gp120 from HIV-1 virions induced by soluble CD4. |
| title_short | Dissociation of gp120 from HIV-1 virions induced by soluble CD4. |
| title_sort | dissociation of gp120 from hiv 1 virions induced by soluble cd4 |
| work_keys_str_mv | AT moorej dissociationofgp120fromhiv1virionsinducedbysolublecd4 AT mckeatingj dissociationofgp120fromhiv1virionsinducedbysolublecd4 AT weissr dissociationofgp120fromhiv1virionsinducedbysolublecd4 AT sattentauq dissociationofgp120fromhiv1virionsinducedbysolublecd4 |