Synthetic tools for studying the chemical biology of InsP8

To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural an...

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Main Authors: Riley, A, Wang, H, Shears, S, Potter, BVL
格式: Journal article
语言:English
出版: Royal Society of Chemistry 2015