Synthetic tools for studying the chemical biology of InsP8

To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural an...

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Bibliographic Details
Main Authors: Riley, A, Wang, H, Shears, S, Potter, BVL
Format: Journal article
Language:English
Published: Royal Society of Chemistry 2015