Synthetic tools for studying the chemical biology of InsP8
To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural an...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
Royal Society of Chemistry
2015
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| _version_ | 1826268739754000384 |
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| author | Riley, A Wang, H Shears, S Potter, BVL |
| author_facet | Riley, A Wang, H Shears, S Potter, BVL |
| author_sort | Riley, A |
| collection | OXFORD |
| description | To synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism. |
| first_indexed | 2024-03-06T21:14:14Z |
| format | Journal article |
| id | oxford-uuid:3f38c02c-f6ee-4177-985b-aa636c5f0de7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:14:14Z |
| publishDate | 2015 |
| publisher | Royal Society of Chemistry |
| record_format | dspace |
| spelling | oxford-uuid:3f38c02c-f6ee-4177-985b-aa636c5f0de72022-03-26T14:30:36ZSynthetic tools for studying the chemical biology of InsP8Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f38c02c-f6ee-4177-985b-aa636c5f0de7EnglishSymplectic Elements at OxfordRoyal Society of Chemistry2015Riley, AWang, HShears, SPotter, BVLTo synthesise stabilised mimics of InsP8, the most phosphorylated inositol phosphate signalling molecule in Nature, we replaced its two diphosphate (PP) groups with either phosphonoacetate (PA) or methylenebisphosphonate (PCP) groups. Utility of the PA and PCP analogues was verified by structural and biochemical analyses of their interactions with enzymes of InsP8 metabolism. |
| spellingShingle | Riley, A Wang, H Shears, S Potter, BVL Synthetic tools for studying the chemical biology of InsP8 |
| title | Synthetic tools for studying the chemical biology of InsP8 |
| title_full | Synthetic tools for studying the chemical biology of InsP8 |
| title_fullStr | Synthetic tools for studying the chemical biology of InsP8 |
| title_full_unstemmed | Synthetic tools for studying the chemical biology of InsP8 |
| title_short | Synthetic tools for studying the chemical biology of InsP8 |
| title_sort | synthetic tools for studying the chemical biology of insp8 |
| work_keys_str_mv | AT rileya synthetictoolsforstudyingthechemicalbiologyofinsp8 AT wangh synthetictoolsforstudyingthechemicalbiologyofinsp8 AT shearss synthetictoolsforstudyingthechemicalbiologyofinsp8 AT potterbvl synthetictoolsforstudyingthechemicalbiologyofinsp8 |