Regioselective Dieckmann cyclisations leading to enantiopure highly functionalised tetramic acid derivatives

Regioselective Dieckmann cyclisations using an N-acyloxazolidine derived from L-serine give substituted tetramic acids in high yield and enantioselectivity. The products are easily deprotected under mild conditions to give hydroxymethyltetramic acids.

Bibliographic Details
Main Authors: Andrews, MD, Brewster, A, Crapnell, K, Ibbett, A, Jones, T, Moloney, M, Prout, K, Watkin, D
Format: Journal article
Language:English
Published: 1998