Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

MYH-associated polyposis is a recently described, autosomal recessive condition comprising multiple colorectal adenomas and cancer. This disease is caused by germline mutations in the base excision repair (BER) gene MYH. Genes involved in the BER pathway are thus good candidates for involvement in t...

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書目詳細資料
Main Authors: Halford, SE, Rowan, A, Lipton, L, Sieber, O, Pack, K, Thomas, H, Hodgson, S, Bodmer, W, Tomlinson, I
格式: Journal article
語言:English
出版: 2003