Nonspecific bridging-induced attraction drives clustering of DNA-binding proteins and genome organization.

Nonspecific bridging-induced attraction drives clustering of DNA-binding proteins and genome organization.

Molecular dynamics simulations are used to model proteins that diffuse to DNA, bind, and dissociate; in the absence of any explicit interaction between proteins, or between templates, binding spontaneously induces local DNA compaction and protein aggregation. Small bivalent proteins form into rows [...

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Những tác giả chính:	Brackley, C, Taylor, S, Papantonis, A, Cook, P, Marenduzzo, D
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2013

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