Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

The Kaplan-Meier (K-M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one cause of failure. In reality, failures are ca...

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Detalhes bibliográficos
Principais autores: Dahal, P, Simpson, J, Dorsey, G, Guérin, P, Price, R, Stepniewska, K
Formato: Journal article
Idioma:English
Publicado em: BioMed Central 2017