Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

The Kaplan-Meier (K-M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one cause of failure. In reality, failures are ca...

书目详细资料
Main Authors:	Dahal, P, Simpson, J, Dorsey, G, Guérin, P, Price, R, Stepniewska, K
格式:	Journal article
语言:	English
出版:	BioMed Central 2017

相似书籍

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges
由: Prabin Dahal, et al.
出版: (2017-10-01)

Optimising statistical methodologies for estimating antimalarial efficacy for uncomplicated Plasmodium falciparum malaria
由: Dahal, P
出版: (2018)

Global estimation of anti-malarial drug effectiveness for the treatment of uncomplicated Plasmodium falciparum malaria 1991-2019
由: Rathmes, G, et al.
出版: (2020)

Global estimation of anti-malarial drug effectiveness for the treatment of uncomplicated Plasmodium falciparum malaria 1991–2019
由: Giulia Rathmes, et al.
出版: (2020-10-01)

Therapeutic efficacy of artemether–lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria from three highly malarious states in India
由: Praveen K. Bharti, et al.
出版: (2016-10-01)

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review
由: Saito, M, et al.
出版: (2017)

<it>Plasmodium falciparum </it>population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria
由: Carlsson Anja M, et al.
出版: (2011-12-01)

Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparum malaria in Cambodia, 2009–2011: a randomized controlled trial and brief review
由: Dysoley Lek, et al.
出版: (2022-09-01)

On the adequacy of a 28 day follow-up period for artemether limefantrine against uncomplicated plasmodium falciparum malaria
由: Dahal, P
出版: (2017)

Therapeutic efficacy of artesunate in the treatment of uncomplicated <it>Plasmodium falciparum</it> malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China-Myanmar border
由: Huang Fang, et al.
出版: (2012-08-01)

Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
由: Kloprogge, F, et al.
出版: (2014)

Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria
由: James M. Colborn, et al.
出版: (2015-01-01)

Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria.
由: Chiodini, P, et al.
出版: (1995)

Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
由: Kloprogge, F, et al.
出版: (2013)

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
由: Tarning, J, et al.
出版: (2012)

Efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Nepal
由: Prakash Ghimire, et al.
出版: (2018-08-01)

Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum.
由: Monatrakul, P, et al.
出版: (2010)

Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria.
由: Tarning, J, et al.
出版: (2009)

Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria.
由: Pukrittayakamee, S, et al.
出版: (2003)

Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.
由: Tarning, J, et al.
出版: (2013)

Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania
由: Billy Ngasala, et al.
出版: (2024-03-01)

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated <it>Plasmodium falciparum</it> malaria in Uganda
由: Tarning Joel, et al.
出版: (2012-08-01)

The effect of dose on the antimalarial efficacy of artesunate-mefloquine against Plasmodium falciparum malaria: a protocol for systematic review and individual patient data (IPD) meta-analysis
由: Mansoor, R, et al.
出版: (2019)

The consequences of censoring new infections when deriving antimalarial efficacy against uncomplicated P. falciparum malaria
由: Dahal, P
出版: (2017)

Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria.
由: Adam, I, et al.
出版: (2012)

Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria
由: Adam, I, et al.
出版: (2012)

Artemisinin-based combination therapy for uncomplicated <it>Plasmodium falciparum </it>malaria in Colombia
由: Taylor Walter RJ, et al.
出版: (2007-02-01)

Factors contributing to anemia after uncomplicated falciparum malaria.
由: Price, R, et al.
出版: (2001)

Modulating effects of plasma containing anti-malarial antibodies on <it>in vitro </it>anti-malarial drug susceptibility in <it>Plasmodium falciparum</it>
由: Udomsangpetch Rachanee, et al.
出版: (2010-11-01)

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
由: Mcgready, R, et al.
出版: (2006)

Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria.
由: Stepniewska, K, et al.
出版: (2006)

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
由: McGready, R, et al.
出版: (2009)

Risk factors for gametocyte carriage in uncomplicated falciparum malaria.
由: Price, R, et al.
出版: (1999)

Anti-malarial drugs: how effective are they against <it>Plasmodium falciparum </it>gametocytes?
由: Peatey Christopher L, et al.
出版: (2012-02-01)

Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria
由: Stepniewska Kasia, et al.
出版: (2006-12-01)

Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated <it>Plasmodium falciparum </it>malaria in Senegal
由: Faye Oumar, et al.
出版: (2007-06-01)

<it>In vivo </it>efficacy of artemether-lumefantrine against uncomplicated <it>Plasmodium falciparum </it>malaria in Central Ethiopia
由: Jima Daddi, et al.
出版: (2011-07-01)

Efficacy of artesunate-amodiaquine and artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria in Madagascar, 2018
由: Catherine M. Dentinger, et al.
出版: (2021-11-01)

Therapeutic efficacy and tolerability of artemether–lumefantrine for uncomplicated Plasmodium falciparum malaria in Niger, 2020
由: Ibrahim M. Laminou, et al.
出版: (2024-05-01)

Evolution of genetic markers for drug resistance after the introduction of dihydroartemisinin–piperaquine as first-line anti-malarial treatment for uncomplicated falciparum malaria in Indonesia
由: Rahmasari, FV, et al.
出版: (2023)