Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges

The Kaplan-Meier (K-M) method is currently the preferred approach to derive an efficacy estimate from anti-malarial trial data. In this approach event times are assumed to be continuous and estimates are generated on the assumption that there is only one cause of failure. In reality, failures are ca...

Descripció completa

Dades bibliogràfiques
Autors principals:	Dahal, P, Simpson, J, Dorsey, G, Guérin, P, Price, R, Stepniewska, K
Format:	Journal article
Idioma:	English
Publicat:	BioMed Central 2017

Ítems similars

Statistical methods to derive efficacy estimates of anti-malarials for uncomplicated Plasmodium falciparum malaria: pitfalls and challenges
per: Prabin Dahal, et al.
Publicat: (2017-10-01)

Optimising statistical methodologies for estimating antimalarial efficacy for uncomplicated Plasmodium falciparum malaria
per: Dahal, P
Publicat: (2018)

Global estimation of anti-malarial drug effectiveness for the treatment of uncomplicated Plasmodium falciparum malaria 1991-2019
per: Rathmes, G, et al.
Publicat: (2020)

Methodology of assessment and reporting of safety in anti-malarial treatment efficacy studies of uncomplicated falciparum malaria in pregnancy: a systematic literature review
per: Saito, M, et al.
Publicat: (2017)

Efficacy of three anti-malarial regimens for uncomplicated Plasmodium falciparum malaria in Cambodia, 2009–2011: a randomized controlled trial and brief review
per: Dysoley Lek, et al.
Publicat: (2022-09-01)

<it>Plasmodium falciparum </it>population dynamics during the early phase of anti-malarial drug treatment in Tanzanian children with acute uncomplicated malaria
per: Carlsson Anja M, et al.
Publicat: (2011-12-01)

Therapeutic efficacy of artesunate in the treatment of uncomplicated <it>Plasmodium falciparum</it> malaria and anti-malarial, drug-resistance marker polymorphisms in populations near the China-Myanmar border
per: Huang Fang, et al.
Publicat: (2012-08-01)

On the adequacy of a 28 day follow-up period for artemether limefantrine against uncomplicated plasmodium falciparum malaria
per: Dahal, P
Publicat: (2017)

Population pharmacokinetics of quinine in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
per: Kloprogge, F, et al.
Publicat: (2014)

Human Gene Expression in Uncomplicated Plasmodium falciparum Malaria
per: James M. Colborn, et al.
Publicat: (2015-01-01)

Efficacy of artesunate-amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria in mainland Tanzania
per: Billy Ngasala, et al.
Publicat: (2024-03-01)

Evaluation of atovaquone in the treatment of patients with uncomplicated Plasmodium falciparum malaria.
per: Chiodini, P, et al.
Publicat: (1995)

Population Pharmacokinetics of Lumefantrine in Pregnant and Nonpregnant Women With Uncomplicated Plasmodium falciparum Malaria in Uganda.
per: Kloprogge, F, et al.
Publicat: (2013)

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated Plasmodium falciparum malaria in Uganda.
per: Tarning, J, et al.
Publicat: (2012)

The consequences of censoring new infections when deriving antimalarial efficacy against uncomplicated P. falciparum malaria
per: Dahal, P
Publicat: (2017)

Modulating effects of plasma containing anti-malarial antibodies on in vitro anti-malarial drug susceptibility in Plasmodium falciparum.
per: Monatrakul, P, et al.
Publicat: (2010)

The effect of dose on the antimalarial efficacy of artesunate-mefloquine against Plasmodium falciparum malaria: a protocol for systematic review and individual patient data (IPD) meta-analysis
per: Mansoor, R, et al.
Publicat: (2019)

Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malaria.
per: Tarning, J, et al.
Publicat: (2009)

Therapeutic efficacy and tolerability of artemether–lumefantrine for uncomplicated Plasmodium falciparum malaria in Niger, 2020
per: Ibrahim M. Laminou, et al.
Publicat: (2024-05-01)

Efficacy and tolerability of four antimalarial combinations in the treatment of uncomplicated <it>Plasmodium falciparum </it>malaria in Senegal
per: Faye Oumar, et al.
Publicat: (2007-06-01)

Pharmacokinetic properties of artemether, dihydroartemisinin, lumefantrine, and quinine in pregnant women with uncomplicated plasmodium falciparum malaria in Uganda.
per: Tarning, J, et al.
Publicat: (2013)

Quinine pharmacokinetic-pharmacodynamic relationships in uncomplicated falciparum malaria.
per: Pukrittayakamee, S, et al.
Publicat: (2003)

Efficacy and safety of dihydroartemisinin–piperaquine for the treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax malaria in Papua and Sumatra, Indonesia
per: Puji B. S. Asih, et al.
Publicat: (2022-03-01)

Population pharmacokinetics of Artemether and dihydroartemisinin in pregnant women with uncomplicated <it>Plasmodium falciparum</it> malaria in Uganda
per: Tarning Joel, et al.
Publicat: (2012-08-01)

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.
per: Karema, C, et al.
Publicat: (2006)

Efficacy of three artemisinin combination therapies for the treatmentof uncomplicated <it>Plasmodium falciparum </it>malaria in the Republic of Congo
per: Libama François, et al.
Publicat: (2006-11-01)

Efficacy of sulfadoxine-pyrimethamine and mefloquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Amazon basin of Peru
per: Alan J. Magill, et al.
Publicat: (2004-06-01)

Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria.
per: Adam, I, et al.
Publicat: (2012)

Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria
per: Adam, I, et al.
Publicat: (2012)

Factors contributing to anemia after uncomplicated falciparum malaria.
per: Price, R, et al.
Publicat: (2001)

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
per: Mcgready, R, et al.
Publicat: (2006)

The pharmacokinetics of artemether and lumefantrine in pregnant women with uncomplicated falciparum malaria.
per: McGready, R, et al.
Publicat: (2009)

Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria.
per: Stepniewska, K, et al.
Publicat: (2006)

Anti-malarial drugs: how effective are they against <it>Plasmodium falciparum </it>gametocytes?
per: Peatey Christopher L, et al.
Publicat: (2012-02-01)

Risk factors for gametocyte carriage in uncomplicated falciparum malaria.
per: Price, R, et al.
Publicat: (1999)

Evolution of genetic markers for drug resistance after the introduction of dihydroartemisinin–piperaquine as first-line anti-malarial treatment for uncomplicated falciparum malaria in Indonesia
per: Rahmasari, FV, et al.
Publicat: (2023)

Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria
per: Stepniewska Kasia, et al.
Publicat: (2006-12-01)

Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial.
per: Piola, P, et al.
Publicat: (2010)

Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trial.
per: Piola, P, et al.
Publicat: (2010)

In vivo efficacy and safety of artemether–lumefantrine and amodiaquine–artesunate for uncomplicated Plasmodium falciparum malaria in Mozambique, 2018
per: Abel Nhama, et al.
Publicat: (2021-10-01)