Very large treatment effects in randomised trials as an empirical marker to indicate whether subsequent trials are necessary: meta-epidemiological assessment

<strong>Objective:</strong> Most healthcare interventions provide modest benefits, but occasionally trials report very large improvements over existing treatments or inactive controls. This often leads to speculation that further trials may be unnecessary. We examined whether a very larg...

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Библиографические подробности
Главные авторы: Nagendran, M, Pereira, T, Kiew, G, Altman, D, Maruthappu, M, Ioannidis, J, McCulloch, P
Формат: Journal article
Язык:English
Опубликовано: BMJ Publishing Group 2016