Very large treatment effects in randomised trials as an empirical marker to indicate whether subsequent trials are necessary: meta-epidemiological assessment

<strong>Objective:</strong> Most healthcare interventions provide modest benefits, but occasionally trials report very large improvements over existing treatments or inactive controls. This often leads to speculation that further trials may be unnecessary. We examined whether a very larg...

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Bibliographic Details
Main Authors: Nagendran, M, Pereira, T, Kiew, G, Altman, D, Maruthappu, M, Ioannidis, J, McCulloch, P
Format: Journal article
Language:English
Published: BMJ Publishing Group 2016