DNA polymerase conformational dynamics and the role of fidelity-conferring residues: Insights from computational simulations

DNA polymerase conformational dynamics and the role of fidelity-conferring residues: Insights from computational simulations

Herein we investigate the molecular bases of DNA polymerase I conformational dynamics that underlie the replication fidelity of the enzyme. Such fidelity is determined by conformational changes that promote the rejection of incorrect nucleotides before the chemical ligation step. We report a compreh...

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Bibliografische gegevens
Hoofdauteurs:	Meli, M, Sustarsic, M, Craggs, T, Kapanidis, A, Colombo, G
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	Frontiers Media 2016

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