T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.
The T cell surface glycoprotein CD8 enhances T cell antigen recognition by binding to MHC class I molecules. We show that human CD8 alphaalpha binds to the MHC class I molecule HLA-A2 with an extremely low affinity (Kd approximately 0.2 mM at 37 degrees C) and with kinetics that are between 2 and 3...
Главные авторы: | , , , , , , , |
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Формат: | Journal article |
Язык: | English |
Опубликовано: |
1999
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