T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.

T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics.

The T cell surface glycoprotein CD8 enhances T cell antigen recognition by binding to MHC class I molecules. We show that human CD8 alphaalpha binds to the MHC class I molecule HLA-A2 with an extremely low affinity (Kd approximately 0.2 mM at 37 degrees C) and with kinetics that are between 2 and 3...

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Dades bibliogràfiques
Autors principals:	Wyer, JR, Willcox, B, Gao, G, Gerth, U, Davis, S, Bell, J, Van Der Merwe, P, Jakobsen, B
Format:	Journal article
Idioma:	English
Publicat:	1999

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