High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Selective protein kinase inhibitors have only been developed against a small number of kinase targets. Here we demonstrate that "high-throughput kinase profiling" is an efficient method for the discovery of lead compounds for established as well as unexplored kinase targets. We screened a...

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Bibliographic Details
Main Authors: Miduturu, C, Deng, X, Kwiatkowski, N, Yang, W, Brault, L, Filippakopoulos, P, Chung, E, Yang, Q, Schwaller, J, Knapp, S, King, R, Lee, J, Herrgard, S, Zarrinkar, P, Gray, N
Format: Journal article
Language:English
Published: 2011