Quantitative proteomic analysis of purified yeast kinetochores identifies a PP1 regulatory subunit.

The kinetochore is a macromolecular complex that controls chromosome segregation and cell cycle progression. When sister kinetochores make bioriented attachments to microtubules from opposite poles, the spindle checkpoint is silenced. Biorientation and the spindle checkpoint are regulated by a balan...

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Bibliographic Details
Main Authors: Akiyoshi, B, Nelson, C, Ranish, J, Biggins, S
Format: Journal article
Language:English
Published: 2009