Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore.

Nucleobase recognition in ssDNA at the central constriction of the alpha-hemolysin pore.

Nanopores are under investigation for single-molecule DNA sequencing. The alpha-hemolysin (alphaHL) protein nanopore contains three recognition points capable of nucleobase discrimination in individual immobilized ssDNA molecules. We have modified the recognition point R(1) by extensive mutagenesis...

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Detalles Bibliográficos
Main Authors:	Stoddart, D, Heron, A, Klingelhoefer, J, Mikhailova, E, Maglia, G, Bayley, H
Formato:	Journal article
Idioma:	English
Publicado:	2010

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