Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.

Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.

OBJECTIVE: Fibrosis is excessive scarring caused by the accumulation and contraction of extracellular matrix proteins and is a common end pathway in many chronic diseases, including scleroderma (systemic sclerosis [SSc]). Indeed, pulmonary fibrosis is a major cause of death in SSc. Transforming gro...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Shi-wen, X, Kennedy, L, Renzoni, E, Bou-Gharios, G, du Bois, R, Black, C, Denton, C, Abraham, D, Leask, A
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2007

समान संसाधन

Bosentan attenuates the profibrotic gene expression profile of lung fibroblasts in scleroderma
द्वारा: Shiwen, X, और अन्य
प्रकाशित: (2006)

Response of human lung fibroblast cells to stimulation by endothelin-1: Involvement of ras/MEK/ERK and PI3 kinase
द्वारा: Shiwen, X, और अन्य
प्रकाशित: (2003)

Activation of key profibrotic mechanisms in transgenic fibroblasts expressing kinase-deficient type II Transforming growth factor-{beta} receptor (T{beta}RII{delta}k).
द्वारा: Denton, C, और अन्य
प्रकाशित: (2005)

Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK.
द्वारा: Xu, S, और अन्य
प्रकाशित: (2004)

Endogenous endothelin-1 signaling contributes to type I collagen and CCN2 overexpression in fibrotic fibroblasts.
द्वारा: Shi-Wen, X, और अन्य
प्रकाशित: (2007)

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.
द्वारा: Shi-Wen, X, और अन्य
प्रकाशित: (2004)

Bosentan alleviates the pro-fibrotic phenotype of lung scleroderma fibroblasts: Implications for treatment of scleroderma.
द्वारा: Leask, A, और अन्य
प्रकाशित: (2005)

Novel transforming growth factor beta transcriptional targets in adult lung fibroblasts indentified by microarray analysis
द्वारा: Renzoni, E, और अन्य
प्रकाशित: (2004)

Fibroblast matrix gene expression and connective tissue remodeling: role of endothelin-1.
द्वारा: Shi-Wen, X, और अन्य
प्रकाशित: (2001)

CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.
द्वारा: Shi-wen, X, और अन्य
प्रकाशित: (2006)

Gene expression profiling reveals novel TGFbeta targets in adult lung fibroblasts.
द्वारा: Renzoni, E, और अन्य
प्रकाशित: (2004)

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.
द्वारा: Chen, Y, और अन्य
प्रकाशित: (2005)

Profibrotic Effects of Endothelin-1 on Fibroblasts Are Mediated by Aldosterone In Vitro: Relevance to the Pathogenesis and Therapy of Systemic Sclerosis and Pulmonary Arterial Hypertension
द्वारा: Giuseppe Argentino, और अन्य
प्रकाशित: (2022-10-01)

Platelet-derived growth factor-beta receptor activation is essential for fibroblast and pericyte recruitment during cutaneous wound healing.
द्वारा: Rajkumar, V, और अन्य
प्रकाशित: (2006)

CTGF Contributes to collagen type I expression in the bleomycin model of lung fibrosis and in human pulmonary fibroblasts by MAPK dependent transcriptional activation
द्वारा: Porticos, M, और अन्य
प्रकाशित: (2009)

Gene expression profiling of fibroblasts in response to applied bio-mechanical force
द्वारा: Eastwood, M, और अन्य
प्रकाशित: (2007)

Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts
द्वारा: Pearson Jeremy D, और अन्य
प्रकाशित: (2004-11-01)

A novel TGF-beta response element located in the human collagen type I alpha 2 far upstream enhancer is SMAD-independent
द्वारा: Ponticos, M, और अन्य
प्रकाशित: (2006)

Regulation of Cellular Senescence Is Independent from Profibrotic Fibroblast-Deposited ECM
द्वारा: Kaj E. C. Blokland, और अन्य
प्रकाशित: (2021-06-01)

Substrate Stiffness and Stretch Regulate Profibrotic Mechanosignaling in Pulmonary Arterial Adventitial Fibroblasts
द्वारा: Ariel Wang, और अन्य
प्रकाशित: (2021-04-01)

Activation of a fibroblast-specific enhancer of the proalpha2(I) collagen gene in tight-skin mice.
द्वारा: Denton, C, और अन्य
प्रकाशित: (2001)

GENE EXPRESSION PROFILING OF CONNECTIVE TISSUE FIBROBLASTS IN RESPONSE TO APPLIED BIO-MECHANICAL FORCE
द्वारा: Shiwen, X, और अन्य
प्रकाशित: (2003)

IL-17A exacerbates fibrosis by promoting the proinflammatory and profibrotic function of orbital fibroblasts in TAO
द्वारा: Fang, S, और अन्य
प्रकाशित: (2016)

Blocking endothelin: breaking new ground
द्वारा: R. M. du Bois
प्रकाशित: (2007-08-01)

Profibrotic behavior of fibroblasts derived from patients that develop posttraumatic shoulder stiffness
द्वारा: Benjamin A. Hendy, और अन्य
प्रकाशित: (2023-02-01)

Paeonol inhibits profibrotic signaling and HOTAIR expression in fibrotic buccal mucosal fibroblasts
द्वारा: Dennis Chun-Yu Ho, और अन्य
प्रकाशित: (2022-05-01)

Combination of roflumilast with a beta-2 adrenergic receptor agonist inhibits proinflammatory and profibrotic mediator release from human lung fibroblasts
द्वारा: Tannheimer Stacey L, और अन्य
प्रकाशित: (2012-03-01)

Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: insight into the functional role of mutant fibrillin-1.
द्वारा: Menon, R, और अन्य
प्रकाशित: (2006)

The influence of the endocannabinoid system on the profibrotic profile of cardiac fibroblasts associated with Duchenne Muscular Dystrophy
द्वारा: Lesia Savchenko, और अन्य
प्रकाशित: (2024-11-01)

Pharmacological Stimulation of Soluble Guanylate Cyclase Counteracts the Profibrotic Activation of Human Conjunctival Fibroblasts
द्वारा: Bianca Saveria Fioretto, और अन्य
प्रकाशित: (2024-02-01)

Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis
द्वारा: Minxue Jia, और अन्य
प्रकाशित: (2023-04-01)

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.
द्वारा: Wiparat Manuyakorn, और अन्य
प्रकाशित: (2016-01-01)

The uPA System Differentially Alters Fibroblast Fate and Profibrotic Ability in Skin Fibrosis
द्वारा: Ming-Li Zou, और अन्य
प्रकाशित: (2022-03-01)

Stimulation of Transforming Growth Factor-β1-Induced Endothelial-To-Mesenchymal Transition and Tissue Fibrosis by Endothelin-1 (ET-1): A Novel Profibrotic Effect of ET-1.
द्वारा: Peter J Wermuth, और अन्य
प्रकाशित: (2016-01-01)

Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.
द्वारा: Sonnylal, S, और अन्य
प्रकाशित: (2010)

Activation of STAT3 integrates common profibrotic pathways to promote fibroblast activation and tissue fibrosis
द्वारा: Debomita Chakraborty, और अन्य
प्रकाशित: (2017-10-01)

IL-11 Is Elevated and Drives the Profibrotic Phenotype Transition of Orbital Fibroblasts in Thyroid-Associated Ophthalmopathy
द्वारा: Pengsen Wu, और अन्य
प्रकाशित: (2022-02-01)

Profibrotic role of transcription factor SP1 in cross-talk between fibroblasts and M2 macrophages
द्वारा: Peng Feng, और अन्य
प्रकाशित: (2023-12-01)

Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts
द्वारा: Maurizio Cutolo, और अन्य
प्रकाशित: (2018-05-01)

Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts
द्वारा: Elena Raschi, और अन्य
प्रकाशित: (2018-08-01)