Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine

Impaired cardiac contractile function in AGAT knockout mice devoid of creatine is rescued by homoarginine but not creatine

Creatine buffers cellular ATP via the creatine kinase reaction. Creatine levels are reduced in heart failure, but their contribution to pathophysiology is unclear. Arginine:glycine amidinotransferase (AGAT) in the kidney catalyses both the first step in creatine biosynthesis as well as homoarginine...

Полное описание

Библиографические подробности
Главные авторы:	Faller, K, Atzler, D, McAndrew, D, Zervou, S, Whittington, H, Simon, J, Aksentijevic, D, Hove, M, Choe, C, Isbrandt, D, Casadei, B, Schneider, J, Neubauer, S, Lygate, C
Формат:	Journal article
Язык:	English
Опубликовано:	Oxford University Press 2017

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