Mechanosensing in T lymphocyte activation.

Mechanical forces play an increasingly recognized role in modulating cell function. This report demonstrates mechanosensing by T cells, using polyacrylamide gels presenting ligands to CD3 and CD28. Naive CD4 T cells exhibited stronger activation, as measured by attachment and secretion of IL-2, with...

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Bibliographic Details
Main Authors: Judokusumo, E, Tabdanov, E, Kumari, S, Dustin, M, Kam, L
Format: Journal article
Language:English
Published: 2012