CTLs target Th cells that acquire bystander MHC class I-peptide complex from APCs.

CTLs can acquire MHC class I-peptide complexes from their target cells, whereas CD4(+) T cells obtain MHC class II-peptide complexes from APCs in a TCR-specific manner. As a consequence, Ag-specific CTL can kill each other (fratricide) or CD4(+) T cells become APCs themselves. The purpose of the acq...

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Autors principals: Cox, J, Mcmichael, A, Screaton, G, Xu, X
Format: Journal article
Idioma:English
Publicat: 2007