CTLs target Th cells that acquire bystander MHC class I-peptide complex from APCs.

CTLs target Th cells that acquire bystander MHC class I-peptide complex from APCs.

CTLs can acquire MHC class I-peptide complexes from their target cells, whereas CD4(+) T cells obtain MHC class II-peptide complexes from APCs in a TCR-specific manner. As a consequence, Ag-specific CTL can kill each other (fratricide) or CD4(+) T cells become APCs themselves. The purpose of the acq...

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Bibliografiske detaljer
Main Authors:	Cox, J, Mcmichael, A, Screaton, G, Xu, X
Format:	Journal article
Sprog:	English
Udgivet:	2007

Lignende værker

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