CTLs target Th cells that acquire bystander MHC class I-peptide complex from APCs.
CTLs can acquire MHC class I-peptide complexes from their target cells, whereas CD4(+) T cells obtain MHC class II-peptide complexes from APCs in a TCR-specific manner. As a consequence, Ag-specific CTL can kill each other (fratricide) or CD4(+) T cells become APCs themselves. The purpose of the acq...
Main Authors: | Cox, J, Mcmichael, A, Screaton, G, Xu, X |
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פורמט: | Journal article |
שפה: | English |
יצא לאור: |
2007
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