Immunogen design to focus the B-cell repertoire.
PURPOSE OF REVIEW: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs). RECENT FINDINGS: The combined use of structural biology and deep sequencing of antigen-specific B-cell l...
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1826268946412601344 |
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| author | Sattentau, Q |
| author_facet | Sattentau, Q |
| author_sort | Sattentau, Q |
| collection | OXFORD |
| description | PURPOSE OF REVIEW: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs). RECENT FINDINGS: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens. SUMMARY: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed. |
| first_indexed | 2024-03-06T21:17:20Z |
| format | Journal article |
| id | oxford-uuid:40385091-07ad-4800-a741-b847bbd70c9b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:17:20Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:40385091-07ad-4800-a741-b847bbd70c9b2022-03-26T14:36:48ZImmunogen design to focus the B-cell repertoire.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:40385091-07ad-4800-a741-b847bbd70c9bEnglishSymplectic Elements at Oxford2014Sattentau, QPURPOSE OF REVIEW: This review aims to bring together recent developments relevant to the design of HIV-1 envelope glycoprotein-based immunogens to elicit broadly neutralizing antibodies (bNAbs). RECENT FINDINGS: The combined use of structural biology and deep sequencing of antigen-specific B-cell lineages has allowed cross-sectional and longitudinal views of antibody evolution towards broad and potent neutralization of HIV-1. Recent advances in molecular modelling allied with protein and glycoprotein engineering have fuelled the design of new-generation viral envelope glycoproteins (Env)-based antigens. SUMMARY: Although proof-of-principle for vaccine elicitation of bNAbs to HIV-1 is still lacking, many of the conceptual hurdles are being addressed. |
| spellingShingle | Sattentau, Q Immunogen design to focus the B-cell repertoire. |
| title | Immunogen design to focus the B-cell repertoire. |
| title_full | Immunogen design to focus the B-cell repertoire. |
| title_fullStr | Immunogen design to focus the B-cell repertoire. |
| title_full_unstemmed | Immunogen design to focus the B-cell repertoire. |
| title_short | Immunogen design to focus the B-cell repertoire. |
| title_sort | immunogen design to focus the b cell repertoire |
| work_keys_str_mv | AT sattentauq immunogendesigntofocusthebcellrepertoire |