Managing clustering effects and learning effects in the design and analysis of randomised surgical trials: a review of existing guidance

<p><strong>Background:</strong> The complexities associated with delivering randomised surgical trials, such as clustering effects, by centre or surgeon, and surgical learning, are well known. Despite this, approaches used to manage these complexities, and opinions on these, vary....

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Bibliographic Details
Main Authors: Conroy, EJ, Blazeby, JM, Burnside, G, Cook, JA, Gamble, C
Format: Journal article
Language:English
Published: BioMed Central 2022