A refined model for the TSG-6 link module in complex with hyaluronan: use of defined oligosaccharides to probe structure and function.

Tumor necrosis factor-stimulated gene-6 (TSG-6) is an inflammation-associated hyaluronan (HA)-binding protein that contributes to remodeling of HA-rich extracellular matrices during inflammatory processes and ovulation. The HA-binding domain of TSG-6 consists solely of a Link module, making it a pro...

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Bibliographic Details
Main Authors: Higman, V, Briggs, D, Mahoney, D, Blundell, C, Sattelle, B, Dyer, D, Green, D, DeAngelis, P, Almond, A, Milner, C, Day, A
Format: Journal article
Language:English
Published: 2014