Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis

DNA methylation is an important epigenetic modification that is known to be altered in rheumatoid arthritis synovial fibroblasts (RASF). Here, we compared the status of promoter DNA methylation of SF from patients with very early RA with SF from patients with resolving arthritis, fully established R...

Полное описание

Библиографические подробности
Главные авторы:	Karouzakis, E, Raza, K, Kolling, C, Buckley, C, Gay, S, Filer, A, Ospelt, K
Формат:	Journal article
Опубликовано:	Nature Publishing Group 2018

Схожие документы

Analysis of early changes in DNA methylation in synovial fibroblasts of RA patients before diagnosis
по: Emmanuel Karouzakis, и др.
Опубликовано: (2018-05-01)

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
по: Frank-Bertoncelj, M, и др.
Опубликовано: (2017)

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions
по: Mojca Frank-Bertoncelj, и др.
Опубликовано: (2017-03-01)

Endogenous Galectin-9 Suppresses Apoptosis in Human Rheumatoid Arthritis Synovial Fibroblasts
по: Pearson, MJ, и др.
Опубликовано: (2018)

Genomic responses of mouse synovial fibroblasts during tumor necrosis factor-driven arthritogenesis greatly mimic those in human rheumatoid arthritis
по: Ntougkos, E, и др.
Опубликовано: (2017)

Differential effect of lactate on synovial fibroblast and macrophage effector functions
по: Pucino, V, и др.
Опубликовано: (2023)

Location, location, location: how the tissue microenvironment affects inflammation in RA
по: Buckley, CD, и др.
Опубликовано: (2021)

Differential effect of lactate on synovial fibroblast and macrophage effector functions
по: Valentina Pucino, и др.
Опубликовано: (2023-05-01)

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
по: Montero-Melendez, T, и др.
Опубликовано: (2020)

Natural killer cell and synovial fibroblast cross talk - A role in the pathogenesis of spondyloarthritis
по: Chan, A, и др.
Опубликовано: (2006)

Notch signalling drives synovial fibroblast identity and arthritis pathology
по: Wei, K, и др.
Опубликовано: (2020)

Priming in response to pro-inflammatory cytokines is a feature of adult synovial but not dermal fibroblasts
по: Crowley, T, и др.
Опубликовано: (2017)

Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability
по: Xiangyu Ge, и др.
Опубликовано: (2021-08-01)

Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
по: Trinidad Montero-Melendez, и др.
Опубликовано: (2020-02-01)

A proinflammatory response is mediated by synovial fibroblast and natural killer cell interaction in rheumatoid arthritis and spondyloarthritis
по: Chan, A, и др.
Опубликовано: (2008)

Bromodomain Protein Inhibitors Reorganize the Chromatin of Synovial Fibroblasts
по: Monika Krošel, и др.
Опубликовано: (2023-04-01)

IL-15 expression on RA synovial fibroblasts promotes B cell survival.
по: Marta Benito-Miguel, и др.
Опубликовано: (2012-01-01)

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a proinflammatory phenotype in Rheumatoid Arthritis
по: Wang, Y, и др.
Опубликовано: (2021)

Allele-specific protein binding within the CD40 locus in human synovial fibroblasts and immune cells
по: Caroline Ospelt, и др.
Опубликовано: (2023-10-01)

Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage
по: Croft, AP, и др.
Опубликовано: (2016)

The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts
по: Marietta Armaka, и др.
Опубликовано: (2018-02-01)

TLR3 Ligand Poly(I:C) Exerts Distinct Actions in Synovial Fibroblasts When Delivered by Extracellular Vesicles
по: Mojca Frank-Bertoncelj, и др.
Опубликовано: (2018-01-01)

Ultrasound-detected synovitis and tenosynovitis predict RA in early disease
по: Sahbudin, I, и др.
Опубликовано: (2016)

BRD3 Regulates the Inflammatory and Stress Response in Rheumatoid Arthritis Synovial Fibroblasts
по: Tanja Seifritz, и др.
Опубликовано: (2023-11-01)

STAT3 Mediates the Differential Effects of Oncostatin M and TNFα on RA Synovial Fibroblast and Endothelial Cell Function
по: Megan M. Hanlon, и др.
Опубликовано: (2019-08-01)

Stromal cell markers are differentially expressed in the synovial tissue of patients with early arthritis
по: Choi, I, и др.
Опубликовано: (2017)

Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis
по: Yilin Wang, и др.
Опубликовано: (2021-04-01)

Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells
по: Fangqi Li, и др.
Опубликовано: (2019-08-01)

Identification of a transitional fibroblast functional phenotype in very early rheumatoid arthritis
по: Filer, A, и др.
Опубликовано: (2017)

THE PRODUCTION OF PRO- AND ANTIINFLAMMATORY CYTOKINES BY SYNOVIAL FIBROBLASTS OF PATIENTS WITH RHEUMATOID ARTHRITIS IN VITRO WHEN USING DNA METHYLATION MODULATORS - INVESTIGATIVE STUDY
по: M. A. Shnayder, и др.
Опубликовано: (2019-05-01)

Reprogramming of synovial macrophage metabolism by synovial fibroblasts under inflammatory conditions
по: Noritaka Saeki, и др.
Опубликовано: (2020-11-01)

Fibroblasts as therapeutic targets in rheumatoid arthritis and cancer
по: Maria Juarez, и др.
Опубликовано: (2012-02-01)

The histone acetyl transferases CBP and p300 regulate stress response pathways in synovial fibroblasts at transcriptional and functional levels
по: Monika Krošel, и др.
Опубликовано: (2023-10-01)

The complement system drives local inflammatory tissue priming by metabolic reprogramming of synovial fibroblasts
по: Friščić, J, и др.
Опубликовано: (2021)

Targeting early changes in the synovial microenvironment: a new class of immunomodulatory therapy?
по: Aungier, S, и др.
Опубликовано: (2018)

New Developments in Transcriptomic Analysis of Synovial Tissue
по: Hayley L. Carr, и др.
Опубликовано: (2020-01-01)

The role of rank ligand in RA synovial macrophage-osteoclast differentiation
по: Itonaga, I, и др.
Опубликовано: (2000)

Decrease in articular hypoxia and synovial blood flow at early time points following infliximab and etanercept treatment in rheumatoid arthritis
по: Fisher, B, и др.
Опубликовано: (2016)

Multiomics landscape of synovial fibroblasts in rheumatoid arthritis
по: Haruka Tsuchiya, и др.
Опубликовано: (2021-03-01)

Effective extraction of Xuetongsu and its role in preventing RA synovial hyperplasia by targeting synovial cell migration and apoptosis
по: Yasi Deng, и др.
Опубликовано: (2024-10-01)