Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

Thousands of genetic variants have been identified, which contribute to the development of complex diseases, but determining how to elucidate their biological consequences for translation into clinical benefit is challenging. Conflicting evidence regarding the functional impact of genetic variants i...

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Bibliographic Details
Main Authors: Dendrou, C, Cortes, A, Shipman, L, Evans, H, Attfield, K, Jostins, L, Barber, T, Kaur, G, Balaram Kuttikkatte, S, Leach, O, Desel, C, Faergeman, S, Cheeseman, J, Neville, M, Bell, J, Karpe, F, McVean, G, Fugger, L
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2016